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Active-Site Mutations in the South African Human Immunodeficiency Virus Type 1 Subtype C Protease Have a Significant Impact on Clinical Inhibitor Binding: Kinetic and Thermodynamic Study

Human immunodeficiency virus (HIV) infections in sub-Saharan Africa represent about 56% of global infections. Study of active-site mutations (the V82A single mutation and the V82F I84V double mutation) in the less-studied South African HIV type 1 subtype C (C-SA) protease indicated that neither muta...

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Detalhes bibliográficos
Main Authors: Mosebi, Salerwe, Morris, Lynn, Dirr, Heini W., Sayed, Yasien
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573279/
https://ncbi.nlm.nih.gov/pubmed/18768960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00726-08
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