The Transcription Factor COUP-TFII Is Negatively Regulated by Insulin and Glucose via Foxo1- and ChREBP-Controlled Pathways

COUP-TFII has an important role in regulating metabolism in vivo. We showed this previously by deleting COUP-TFII from pancreatic beta cells in heterozygous mutant mice, which led to abnormal insulin secretion. Here, we report that COUP-TFII expression is reduced in the pancreas and liver of mice re...

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Autori principali: Perilhou, Anaïs, Tourrel-Cuzin, Cécile, Kharroubi, Ilham, Henique, Carole, Fauveau, Véronique, Kitamura, Tadahiro, Magnan, Christophe, Postic, Catherine, Prip-Buus, Carina, Vasseur-Cognet, Mireille
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573225/
https://ncbi.nlm.nih.gov/pubmed/18765640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02211-07
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