Cloning, Expression, and Characterization of Babesia gibsoni Dihydrofolate Reductase-Thymidylate Synthase: Inhibitory Effect of Antifolates on Its Catalytic Activity and Parasite Proliferation

Dihydrofolate reductase-thymidylate synthase (DHFR-TS) is a well-validated antifolate drug target in certain pathogenic apicomplexans, but not in the genus Babesia, including Babesia gibsoni. Therefore, we isolated, cloned, and expressed the wild-type B. gibsoni dhfr-ts gene in Escherichia coli and...

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Auteurs principaux: Aboge, Gabriel O., Jia, Honglin, Terkawi, Mohamad A., Goo, Youn-Kyoung, Nishikawa, Yoshifumi, Sunaga, Fujiko, Namikawa, Kuzuhiko, Tsuji, Naotoshi, Igarashi, Ikuo, Suzuki, Hiroshi, Fujisaki, Kozo, Xuan, Xuenan
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
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Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573109/
https://ncbi.nlm.nih.gov/pubmed/18794380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00384-08
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