Functional and structural basis of the nuclear localization signal in the ZIC3 zinc finger domain

Disruptions in ZIC3 cause heterotaxy, a congenital anomaly of the left–right axis. ZIC3 encodes a nuclear protein with a zinc finger (ZF) domain that contains five tandem C2H2 ZF motifs. Missense mutations in the first ZF motif (ZF1) result in defective nuclear localization, which may underlie the p...

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Detalhes bibliográficos
Main Authors: Hatayama, Minoru, Tomizawa, Tadashi, Sakai-Kato, Kumiko, Bouvagnet, Patrice, Kose, Shingo, Imamoto, Naoko, Yokoyama, Shigeyuki, Utsunomiya-Tate, Naoko, Mikoshiba, Katsuhiko, Kigawa, Takanori, Aruga, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2572694/
https://ncbi.nlm.nih.gov/pubmed/18716025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn239
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