Leukotriene B4 omega-oxidation by human polymorphonuclear leukocytes is inhibited by pyocyanin, a phenazine derivative produced by Pseudomonas aeruginosa.

Human polymorphonuclear leukocytes (PMNL) metabolize the potent chemotaxin leukotriene B4 (LTB4) by omega-oxidation to 20-hydroxyl-LTB4 and 20-carboxy-LTB4. The ability of unstimulated human PMNL to metabolize exogenous LTB4 was found to be inhibited by pyocyanin, a phenazine derivative produced by...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Muller, M, Sorrell, T C
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1992
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC257193/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1316878/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.60.6.2536-2540.1992
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