Stromal mesenteric lymph node cells are essential for the generation of gut-homing T cells in vivo

T cells primed in the gut-draining mesenteric lymph nodes (mLN) are imprinted to express α4β7-integrin and chemokine receptor CCR9, thereby enabling lymphocytes to migrate to the small intestine. In vitro activation by intestinal dendritic cells (DC) or addition of retinoic acid (RA) is sufficient t...

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Bibliographic Details
Main Authors: Hammerschmidt, Swantje I., Ahrendt, Manuela, Bode, Ulrike, Wahl, Benjamin, Kremmer, Elisabeth, Förster, Reinhold, Pabst, Oliver
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Brief Definitive Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2571923/
https://ncbi.nlm.nih.gov/pubmed/18852290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080039
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