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Ephrin-B2-induced Cleavage of EphB2 Receptor Is Mediated by Matrix Metalloproteinases to Trigger Cell Repulsion

EphB receptors provide crucial adhesive and repulsive signals during cell migration and axon guidance, but it is unclear how they switch between these opposing responses. Here we provide evidence of an important role for matrix metalloproteinases (MMPs) in repulsive EphB2 signaling. We found that Ep...

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Autors principals: Lin, Kai-Ti, Sloniowski, Slawomir, Ethell, Douglas W., Ethell, Iryna M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570862/
https://ncbi.nlm.nih.gov/pubmed/18713744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804401200
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