Generation of a Protective T-Cell Response Following Coronavirus Infection of the Central Nervous System Is Not Dependent on IL-12/23 Signaling

The functional role of IL-12 and IL-23 in host defense and disease following viral infection of the CNS was determined. Instillation of mouse hepatitis virus (MHV, a positive-strand RNA virus) into the CNS of mice results in acute encephalitis followed by a chronic immune-mediated demyelinating dise...

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Detalhes bibliográficos
Main Authors: HELD, KATHERINE S., GLASS, WILLIAM G., ORLOVSKY, YEVGENIYA I., SHAMBERGER, KIMBERLY A., PETLEY, TED D., BRANIGAN, PATRICK J., CARTON, JILL M., BECK, HEENA S., CUNNINGHAM, MARK R., BENSON, JACQUELINE M., LANE, THOMAS E.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2008
Assuntos:
Cellular Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570712/
https://ncbi.nlm.nih.gov/pubmed/18570589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vim.2008.0014
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