Tissue-Specific Ablation of Prkar1a Causes Schwannomas by Suppressing Neurofibromatosis Protein Production

Signaling events leading to Schwann cell tumor initiation have been extensively characterized in the context of neurofibromatosis (NF). Similar tumors are also observed in patients with the endocrine neoplasia syndrome Carney complex, which results from inactivating mutations in PRKAR1A. Loss of PRK...

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Detalhes bibliográficos
Main Authors: Jones, Georgette N, Tep, Chhavy, Towns, William H, Mihai, Georgeta, Tonks, Ian D, Kay, Graham F, Schmalbrock, Petra M, Stemmer-Rachamimov, Anat O, Yoon, Sung Ok, Kirschner, Lawrence S
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2570597/
https://ncbi.nlm.nih.gov/pubmed/18953430
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