Hematopoiesis is not clonal in healthy elderly women

Clonality assays, based on X-chromosome inactivation, discriminate active from inactive alleles. Skewing of X-chromosome allelic usage, based on preferential methylation of one of the HUMARA alleles, was reported as evidence of clonal hematopoiesis in approximately 30% of elderly women. Using a quan...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Swierczek, Sabina I., Agarwal, Neeraj, Nussenzveig, Roberto H., Rothstein, Gerald, Wilson, Andrew, Artz, Andrew, Prchal, Josef T.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2008
Pynciau:
Hematopoiesis and Stem Cells
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2569172/
https://ncbi.nlm.nih.gov/pubmed/18641369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-03-143925
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