Prostaglandin E(2)-activated Epac Promotes Neointimal Formation of the Rat Ductus Arteriosus by a Process Distinct from That of cAMP-dependent Protein Kinase A

We have demonstrated that chronic stimulation of the prostaglandin E(2)-cAMP-dependent protein kinase A (PKA) signal pathway plays a critical role in intimal cushion formation in perinatal ductus arteriosus (DA) through promoting synthesis of hyaluronan. We hypothesized that Epac, a newly identified...

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Main Authors: Yokoyama, Utako, Minamisawa, Susumu, Quan, Hong, Akaike, Toru, Suzuki, Sayaka, Jin, Meihua, Jiao, Qibin, Watanabe, Mayumi, Otsu, Koji, Iwasaki, Shiho, Nishimaki, Shigeru, Sato, Motohiko, Ishikawa, Yoshihiro
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Molecular Basis of Cell and Developmental Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568928/
https://ncbi.nlm.nih.gov/pubmed/18697745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804223200
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