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Phosphorylation of MyoGEF on Thr-574 by Plk1 Promotes MyoGEF Localization to the Central Spindle

We reported previously that a guanine nucleotide exchange factor, MyoGEF, localizes to the central spindle, activates RhoA, and is required for cytokinesis. In this study, we have found that Plk1 (polo-like kinase 1) can phosphorylate MyoGEF, thereby recruiting MyoGEF to the central spindle as well...

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Sonraí Bibleagrafaíochta
Main Authors: Asiedu, Michael, Wu, Di, Matsumura, Fumio, Wei, Qize
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568926/
https://ncbi.nlm.nih.gov/pubmed/18694934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801801200
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