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PKC1 Is Essential for Protection against both Oxidative and Nitrosative Stresses, Cell Integrity, and Normal Manifestation of Virulence Factors in the Pathogenic Fungus Cryptococcus neoformans

Cell wall integrity is crucial for fungal growth, survival, and pathogenesis. Responses to environmental stresses are mediated by the highly conserved Pkc1 protein and its downstream components. In this study, we demonstrate that both oxidative and nitrosative stresses activate the PKC1 cell integri...

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Detalhes bibliográficos
Main Authors: Gerik, Kimberly J., Bhimireddy, Sujit R., Ryerse, Jan S., Specht, Charles A., Lodge, Jennifer K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568057/
https://ncbi.nlm.nih.gov/pubmed/18689526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/EC.00146-08
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