Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes

Activity-dependent secretion of brain-derived neurotrophic factor (BDNF) is thought to enhance synaptic plasticity, but the mechanisms controlling extracellular availability and clearance of secreted BDNF are poorly understood. We show that BDNF is secreted in its precursor form (pro-BDNF) and is th...

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Bibliografiska uppgifter
Huvudupphovsmän: Bergami, Matteo, Santi, Spartaco, Formaggio, Elena, Cagnoli, Cinzia, Verderio, Claudia, Blum, Robert, Berninger, Benedikt, Matteoli, Michela, Canossa, Marco
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2008
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2568011/
https://ncbi.nlm.nih.gov/pubmed/18852301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200806137
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