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Systematic Multiscale Parameterization of Heterogeneous Elastic Network Models of Proteins

We present a method to parameterize heterogeneous elastic network models (heteroENMs) of proteins to reproduce the fluctuations observed in atomistic simulations. Because it is based on atomistic simulation, our method allows the development of elastic coarse-grained models of proteins under differe...

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Detalhes bibliográficos
Main Authors: Lyman, Edward, Pfaendtner, Jim, Voth, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567941/
https://ncbi.nlm.nih.gov/pubmed/18658214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.139733
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