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Effect of oral organic nitrates on expression and activity of vascular soluble guanylyl cyclase

BACKGROUND AND PURPOSE: The regulation of vascular soluble guanylyl cyclase (sGC) expression by nitric oxide (NO) is still under discussion. In vitro, NO has been shown to downregulate the expression of sGC but it is unclear if this mechanism is operative in vivo and occurs during nitrate treatment....

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Detalhes bibliográficos
Main Authors: Oppermann, M, Dao, V T-V, Suvorava, T, Bas, M, Kojda, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567882/
https://ncbi.nlm.nih.gov/pubmed/18587420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjp.2008.269
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