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Structural Differences Between Pb(2+)- and Ca(2+)-binding Sites in Proteins: Implications with Respect to Toxicity

Pb(2+) is known to displace physiologically-relevant metal ions in proteins. To investigate potential relationships between Pb(2+)/protein complexes and toxicity, data from the Protein Data Bank were analyzed to compare structural properties of Pb(2+)- and Ca(2+)-binding sites. Results of this analy...

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Bibliographic Details
Main Authors: Kirberger, Michael, Yang, Jenny J
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567809/
https://ncbi.nlm.nih.gov/pubmed/18684507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2008.06.014
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