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Natural selection of FLT1 alleles and their association with malaria resistance in utero

Placental malaria (PM) caused by Plasmodium falciparum contributes significantly to infant mortality in sub-Saharan Africa and is associated with pregnancy loss. We hypothesized that fetal genes that modify PM would be associated with fetal fitness. During PM, placental trophoblasts produce soluble...

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Detalhes bibliográficos
Main Authors: Muehlenbachs, Atis, Fried, Michal, Lachowitzer, Jeff, Mutabingwa, Theonest K., Duffy, Patrick E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2567167/
https://ncbi.nlm.nih.gov/pubmed/18779584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803657105
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