A single amino acid substitution in ORF1 dramatically decreases L1 retrotransposition and provides insight into nucleic acid chaperone activity

L1 is a ubiquitous interspersed repeated sequence in mammals that achieved its high copy number by autonomous retrotransposition. Individual L1 elements within a genome differ in sequence and retrotransposition activity. Retrotransposition requires two L1-encoded proteins, ORF1p and ORF2p. Chimeric...

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Bibliographic Details
Main Authors:	Martin, Sandra L., Bushman, Diane, Wang, Fei, Li, Patrick Wai-Lun, Walker, Ann, Cummiskey, Jessica, Branciforte, Dan, Williams, Mark C.
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2008
Subjects:	Molecular Biology
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2566875/ https://ncbi.nlm.nih.gov/pubmed/18790804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn554
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A single amino acid substitution in ORF1 dramatically decreases L1 retrotransposition and provides insight into nucleic acid chaperone activity

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