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DNA methylation determination by liquid chromatography–tandem mass spectrometry using novel biosynthetic [U-(15)N]deoxycytidine and [U-(15)N]methyldeoxycytidine internal standards
Methylation of the promoter CpG regions regulates gene transcription by inhibiting transcription factor binding. Deoxycytidine methylation may regulate cell differentiation, while aberrations in the process may be involved in cancer etiology and the development of birth defects (e.g. neural tube def...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2566864/ https://ncbi.nlm.nih.gov/pubmed/18718928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn534 |
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