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Induction of cytotoxic T-lymphocyte and antibody responses against highly pathogenic avian influenza virus infection in mice by inoculation of apathogenic H5N1 influenza virus particles inactivated with formalin

We investigated whether a vaccine derived from an apathogenic reassortant type A H5N1 influenza strain could induce immune responses in vivo that mediated protection from highly pathogenic avian influenza virus infection in mice. After two subcutaneous immunizations with formalin-inactivated H5N1 wh...

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Detalhes bibliográficos
Main Authors: Sawai, Toshihiro, Itoh, Yasushi, Ozaki, Hiroichi, Isoda, Norikazu, Okamoto, Kiyoko, Kashima, Yoshitaka, Kawaoka, Yoshihiro, Takeuchi, Yoshihiro, Kida, Hiroshi, Ogasawara, Kazumasa
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566620/
https://ncbi.nlm.nih.gov/pubmed/18205793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2007.02745.x
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