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In Vivo Inactivation of the Mycobacterial Integral Membrane Stearoyl Coenzyme A Desaturase DesA3 by a C-Terminus-Specific Degradation Process

DesA3 (Rv3229c) from Mycobacterium tuberculosis is a membrane-bound stearoyl coenzyme A Δ(9) desaturase that reacts with the oxidoreductase Rv3230c to produce oleic acid. This work provides evidence for a mechanism used by mycobacteria to regulate this essential enzyme activity. DesA3 expressed as a...

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Detalhes bibliográficos
Main Authors: Chang, Yong, Wesenberg, Gary E., Bingman, Craig A., Fox, Brian G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2566213/
https://ncbi.nlm.nih.gov/pubmed/18723625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00585-08
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