Edelfosine Induces an Apoptotic Process in Leishmania infantum That Is Regulated by the Ectopic Expression of Bcl-X(L) and Hrk

The alkyl-lysophospholipids edelfosine and miltefosine induce apoptosis in Leishmania infantum promastigotes. The finding that edelfosine-induced cell death can be regulated by the ectopic expression of the antiapoptotic and proapoptotic members of the Bcl-2 family of proteins Bcl-X(L) and Hrk sugge...

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Detalhes bibliográficos
Main Authors: Alzate, Juan Fernando, Arias, Andrés, Mollinedo, Faustino, Rico, Eva, de la Iglesia-Vicente, Janis, Jiménez-Ruiz, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2565883/
https://ncbi.nlm.nih.gov/pubmed/18644968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01665-07
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