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Col2-Cre recombinase is co-expressed with endogenous type II collagen in embryonic renal epithelium and drives development of polycystic kidney disease following inactivation of ciliary genes

Here we report on the severe defects in renal epithelium induced by the transgenic Col2-Cre line used previously for skeletal tissue-specific gene targeting. We demonstrate that conditional ablation of the Kif3a or Pkd1 genes encoding primary cilium/intraflagellar transport-associated proteins using...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Kolpakova-Hart, Elona, Nicolae, Claudia, Zhou, Jing, Olsen, Bjorn R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2008
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564992/
https://ncbi.nlm.nih.gov/pubmed/18579360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2008.05.002
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