Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett’s oesophagus

OBJECTIVES: Current models of clonal expansion in human Barrett’s oesophagus are based upon heterogenous, flow-purified biopsy analysis taken at multiple segment levels. Detection of identical mutation fingerprints from these biopsy samples led to the proposal that a mutated clone with a selective a...

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Hlavní autoři: Leedham, S J, Preston, S L, McDonald, S A C, Elia, G, Bhandari, P, Poller, D, Harrison, R, Novelli, M R, Jankowski, J A, Wright, N A
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Publishing Group 2008
Témata:
Oesophagus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564832/
https://ncbi.nlm.nih.gov/pubmed/18305067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2007.143339
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