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Ras Pathway Activates Epithelial Na(+) Channel and Decreases Its Surface Expression in Xenopus Oocytes

The small G protein K-Ras2A is rapidly induced by aldosterone in A6 epithelia. In these Xenopus sodium reabsorbing cells, aldosterone rapidly activates preexisting epithelial Na(+) channels (XENaC) via a transcriptionally mediated mechanism. In the Xenopus oocytes expression system, we tested whethe...

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Published in:Mol Biol Cell
Main Authors: Mastroberardino, Luca, Spindler, Benjamin, Forster, Ian, Loffing, Jan, Assandri, Roberta, May, Anne, Verrey, François
Format: Artigo
Language:Inglês
Published: American Society for Cell Biology 1998
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC25648/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9843578/
https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.9.12.3417
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