Type 1 diabetes and the OAS gene cluster: association with splicing polymorphism or haplotype?

BACKGROUND: The 2′,5′‐oligoadenylate synthetase genes (OAS1, OAS2, and OAS3) map to human chromosome 12q24 and encode a family of enzymes pivotal to innate antiviral defence. Recently, the minor allele of an OAS1 single nucleotide polymorphism (SNP) that alters splicing (rs10774671) was found to be...

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Hlavní autoři: Tessier, M‐C, Qu, H‐Q, Fréchette, R, Bacot, F, Grabs, R, Taback, S P, Lawson, M L, Kirsch, S E, Hudson, T J, Polychronakos, C
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2006
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564627/
https://ncbi.nlm.nih.gov/pubmed/16014697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jmg.2005.035212
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