NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

Osteoporosis results from an imbalance in skeletal remodeling that favors bone resorption over bone formation. Bone matrix is degraded by osteoclasts, which differentiate from myeloid precursors in response to the cytokine RANKL. To gain insight into the transcriptional regulation of bone resorption...

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Detalhes bibliográficos
Main Authors: Aliprantis, Antonios O., Ueki, Yasuyoshi, Sulyanto, Rosalyn, Park, Arnold, Sigrist, Kirsten S., Sharma, Sudarshana M., Ostrowski, Michael C., Olsen, Bjorn R., Glimcher, Laurie H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564610/
https://ncbi.nlm.nih.gov/pubmed/18846253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35711
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