NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism

Osteoporosis results from an imbalance in skeletal remodeling that favors bone resorption over bone formation. Bone matrix is degraded by osteoclasts, which differentiate from myeloid precursors in response to the cytokine RANKL. To gain insight into the transcriptional regulation of bone resorption...

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Bibliografiske detaljer
Main Authors: Aliprantis, Antonios O., Ueki, Yasuyoshi, Sulyanto, Rosalyn, Park, Arnold, Sigrist, Kirsten S., Sharma, Sudarshana M., Ostrowski, Michael C., Olsen, Bjorn R., Glimcher, Laurie H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564610/
https://ncbi.nlm.nih.gov/pubmed/18846253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35711
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