A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination

V(D)J recombination is one of the most complex DNA transactions in biology. The RAG complex makes double-strand breaks adjacent to signal sequences and creates hairpin coding ends. Here we find that the kinase activity of the Artemis:DNA-PKcs complex can be activated by hairpin DNA ends in cis, ther...

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Main Authors: Lu, Haihui, Shimazaki, Noriko, Raval, Prafulla, Gu, Jiafeng, Watanabe, Go, Schwarz, Klaus, Swanson, Patrick C., Lieber, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2564285/
https://ncbi.nlm.nih.gov/pubmed/18722175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.05.029
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