Effects of Phosphodiesterase 4 Inhibition on Alveolarization and Hyperoxia Toxicity in Newborn Rats

BACKGROUND: Prolonged neonatal exposure to hyperoxia is associated with high mortality, leukocyte influx in airspaces, and impaired alveolarization. Inhibitors of type 4 phosphodiesterases are potent anti-inflammatory drugs now proposed for lung disorders. The current study was undertaken to determi...

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Main Authors: Méhats, Céline, Franco-Montoya, Marie-Laure, Boucherat, Olivier, Lopez, Emmanuel, Schmitz, Thomas, Zana, Elodie, Evain-Brion, Danièle, Bourbon, Jacques, Delacourt, Christophe, Jarreau, Pierre-Henri
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563688/
https://ncbi.nlm.nih.gov/pubmed/18941502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003445
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