BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact

We have used an inhibiting antibody to determine whether preimmune versus antigen-experienced B cells differ in their requisites for BLyS, a cytokine that controls differentiation and survival. Whereas in vivo BLyS inhibition profoundly reduced naïve B cell numbers and primary immune responses, it h...

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Hauptverfasser: Scholz, Jean L., Crowley, Jenni E., Tomayko, Mary M., Steinel, Natalie, O'Neill, Patrick J., Quinn, William J., Goenka, Radhika, Miller, Juli P., Cho, Yun Hee, Long, Vatana, Ward, Chris, Migone, Thi-Sau, Shlomchik, Mark J., Cancro, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2563088/
https://ncbi.nlm.nih.gov/pubmed/18832171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0807841105
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