Regulation of Akt/FOXO3a/GSK-3β/AR Signaling Network by Isoflavone in Prostate Cancer Cells

We have previously shown that genistein could inhibit Akt activation and down-regulate AR (androgen receptor) and PSA (prostate-specific antigen) expression in prostate cancer (PCa) cells. However, pure genistein showed increased lymph node metastasis in an animal model, but such an adverse effect w...

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Bibliografiset tiedot
Päätekijät: Li, Yiwei, Wang, Zhiwei, Kong, Dejuan, Li, Ran, Sarkar, Sanila H., Sarkar, Fazlul H.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2008
Aiheet:
Mechanisms of Signal Transduction
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2562074/
https://ncbi.nlm.nih.gov/pubmed/18687691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802759200
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