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Genetic Dissection of the Role of Catechol-O-Methyltransferase in Cognition and Stress Reactivity in Mice

The COMT (catechol-O-methyltransferase) gene has been linked to a spectrum of human phenotypes, including cognition, anxiety, pain sensitivity and psychosis. Doubts about its clinical impact exist, however, because of the complexity of human COMT polymorphism and clinical variability. We generated t...

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Autores principales: Papaleo, Francesco, Crawley, Jacqueline N., Song, Jian, Lipska, Barbara K., Pickel, Jim, Weinberger, Daniel R., Chen, Jingshan
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561993/
https://ncbi.nlm.nih.gov/pubmed/18753372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2077-08.2008
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