SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival

The tumor suppressor retinoblastoma protein, Rb, plays a pivotal role in the regulation of cell proliferation and sensitivity to apoptosis through binding to E2F transcription factors. Loss of Rb in response to genotoxic stress or inflammatory cytokines can enhance cell death, in part, by eliminatin...

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Main Authors: Tonnetti, Laura, Netzel-Arnett, Sarah, Darnell, Grant A., Hayes, Tamara, Buzza, Marguerite S., Anglin, Ian E., Suhrbier, Andreas, Antalis, Toni M.
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561898/
https://ncbi.nlm.nih.gov/pubmed/18632617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-5850
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