RBP4 Disrupts Vitamin A Uptake Homeostasis in a STRA6-Deficient Animal Model for Matthew-Wood Syndrome

The cellular uptake of vitamin A from its RBP4-bound circulating form (holo-RBP4) is a homeostatic process that evidently depends on the multidomain membrane protein STRA6. In humans, mutations in STRA6 are associated with Matthew-Wood syndrome, manifested by multisystem developmental malformations....

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Main Authors: Isken, Andrea, Golczak, Marcin, Oberhauser, Vitus, Hunzelmann, Silke, Driever, Wolfgang, Imanishi, Yoshikazu, Palczewski, Krzysztof, von Lintig, Johannes
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561276/
https://ncbi.nlm.nih.gov/pubmed/18316031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.01.009
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