Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production

The role of natural killer (NK) T cells in the development of lupus-like disease in mice is still controversial. We treated NZB/W mice with anti-NK1.1 monoclonal antibodies (mAbs) and our results revealed that administration of either an irrelevant immunoglobulin G2a (IgG2a) mAb or an IgG2a anti-NK1...

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Detalhes bibliográficos
Main Authors: Postól, Edilberto, Meyer, André, Cardillo, Fabíola, de Alencar, Raquel, Pessina, Daniel, Nihei, Jorge, Mariano, Mário, Mengel, José
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561130/
https://ncbi.nlm.nih.gov/pubmed/18397273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2008.02835.x
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