A mouse model for poliovirus neurovirulence identifies mutations that attenuate the virus for humans.
A mutation in the genome of poliovirus type 3 that is known to reduce neurovirulence in humans similarly reduces neurovirulence in mice when incorporated into a mouse-adapted-human poliovirus recombinant. Viral recombinants with a uracil at nucleotide position 472 in the 5'-noncoding regions of thei...
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| Udgivet i: | J Virol |
|---|---|
| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1987
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC255821/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3039178/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.61.9.2917-2920.1987 |
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