Genome Wide Identification of Recessive Cancer Genes by Combinatorial Mutation Analysis

We devised a novel procedure to identify human cancer genes acting in a recessive manner. Our strategy was to combine the contributions of the different types of genetic alterations to loss of function: amino-acid substitutions, frame-shifts, gene deletions. We studied over 20,000 genes in 3 Gigabas...

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Autors principals: Volinia, Stefano, Mascellani, Nicoletta, Marchesini, Jlenia, Veronese, Angelo, Ormondroyd, Elizabeth, Alder, Hansjuerg, Palatini, Jeff, Negrini, Massimo, Croce, Carlo M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2008
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2557123/
https://ncbi.nlm.nih.gov/pubmed/18846217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003380
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