Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

Here we show that blocking the adhesive function of αvβ3 integrin with soluble RGD ligands, such as osteopontin or cilengitide, promoted association of Rab-coupling protein (RCP) with α5β1 integrin and drove RCP-dependent recycling of α5β1 to the plasma membrane and its mobilization to dynamic ruffl...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Caswell, Patrick T., Chan, May, Lindsay, Andrew J., McCaffrey, Mary W., Boettiger, David, Norman, Jim C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2008
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2557049/
https://ncbi.nlm.nih.gov/pubmed/18838556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200804140
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