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QUANTITATIVE STUDIES OF ALLOSTERIC EFFECTS BY BIOINTERACTION CHROMATOGRAPHY: ANALYSIS OF PROTEIN BINDING FOR LOW SOLUBILITY DRUGS

A new chromatographic method was developed for characterizing allosteric interactions between an immobilized binding agent and low solubility compounds. This approach was illustrated by using it to characterize the interactions between tamoxifen and warfarin during their binding to the protein human...

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Detalhes bibliográficos
Main Authors: Chen, Jianzhong, Hage, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556871/
https://ncbi.nlm.nih.gov/pubmed/16615779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac052017b
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