An Intramolecular G-Quadruplex Structure with Mixed Parallel/Antiparallel G-strands Formed in the Human BCL-2 Promoter Region in Solution

[Image: see text] We report the first G-quadruplex structure formed in the promoter region of the human bcl-2. Bcl-2 is a potent oncoprotein that functions as an inhibitor of cell apoptosis and has been found to be aberrantly overexpressed in a wide range of human tumors. A highly GC-rich region ups...

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Main Authors: Dai, Jixun, Dexheimer, Thomas S., Chen, Ding, Carver, Megan, Ambrus, Attila, Jones, Roger A., Yang, Danzhou
פורמט: Artigo
שפה:Inglês
יצא לאור: 2006
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556172/
https://ncbi.nlm.nih.gov/pubmed/16433524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja055636a
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