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Protein Targets of Reactive Electrophiles in Human Liver Microsomes

Liver microsomes are widely used to study xenobiotic metabolism in vitro and covalent binding to microsomal proteins serves as a surrogate marker for toxicity mediated by reactive metabolites. We have applied liquid chromatography-tandem mass spectrometry (LC-MS-MS) to identify protein targets of th...

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Detalhes bibliográficos
Main Authors: Shin, Nah-Young, Liu, Qinfeng, Stamer, Sheryl L., Liebler, Daniel C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2556149/
https://ncbi.nlm.nih.gov/pubmed/17480101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx700031r
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