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Deletion of the origin of replication impairs the ability of polyomavirus DNA to transform cells and to form tandem insertions.
We examined the transforming properties of polyomavirus DNA molecules which can produce a functional large T-antigen but which are cis defective for viral DNA replication. The inability of these molecules to replicate results from the deletion of sequences comprising the viral replication origin. We...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1984
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC255561/ https://ncbi.nlm.nih.gov/pubmed/6321778 |
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