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HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein

Selective inactivation of critical cysteine residues in human immunodeficiency virus type one (HIV-1) was observed after treatment with 4-vinylpyridine (4-VP), with and without the membrane-permeable metal chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)-ethylenediamine (TPEN). Chromatographic analysis...

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Detalhes bibliográficos
Main Authors: Morcock, David R., Thomas, James A., Sowder, Raymond C., Henderson, Louis E., Crise, Bruce J., Gorelick, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553892/
https://ncbi.nlm.nih.gov/pubmed/18304600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2008.01.045
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