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Gating Pore Currents in DIIS4 Mutations of NaV1.4 Associated with Periodic Paralysis: Saturation of Ion Flux and Implications for Disease Pathogenesis

S4 voltage–sensor mutations in CaV1.1 and NaV1.4 channels cause the human muscle disorder hypokalemic periodic paralysis (HypoPP). The mechanism whereby these mutations predispose affected sarcolemma to attacks of sustained depolarization and loss of excitability is poorly understood. Recently, thre...

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Detalhes bibliográficos
Main Authors: Struyk, Arie F., Markin, Vladislav S., Francis, David, Cannon, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553391/
https://ncbi.nlm.nih.gov/pubmed/18824591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200809967
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