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An osteoclast-targeting agent for imaging and therapy of bone metastasis
A hybrid compound (DO3A-BP) featuring a radiometal bifunctional chelator (1,4,7,10-tetraazacyclotetradecane-N,N’,N”,N’”-tetraacetic acid, DOTA) and an osteoclast-targeting moiety (bisphosphonate) was designed and synthesized. The (111)In-labeled complex of DO3A-BP showed significantly elevated uptak...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2553272/ https://ncbi.nlm.nih.gov/pubmed/18692394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.07.092 |
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