Robust Intrapulmonary CD8 T Cell Responses and Protection with an Attenuated N1L Deleted Vaccinia Virus

BACKGROUND: Vaccinia viruses have been used as a model for viral disease and as a protective live vaccine. METHODOLOGY AND PRINCIPAL FINDINGS: We investigated the immunogenicity of an attenuated strain of vaccinia virus engineered to inactivate the N1L gene (vGK5). Using the intranasal route, this r...

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Detalhes bibliográficos
Main Authors: Mathew, Anuja, O'Bryan, Joel, Marshall, William, Kotwal, Girish J., Terajima, Masanori, Green, Sharone, Rothman, Alan L., Ennis, Francis A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553181/
https://ncbi.nlm.nih.gov/pubmed/18830408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003323
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