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Effects of Multiple-Bond Ruptures on Kinetic Parameters Extracted from Force Spectroscopy Measurements: Revisiting Biotin-Streptavidin Interactions

Force spectroscopy measurements of the rupture of the molecular bond between biotin and streptavidin often results in a wide distribution of rupture forces. We attribute the long tail of high rupture forces to the nearly simultaneous rupture of more than one molecular bond. To decrease the number of...

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Détails bibliographiques
Auteurs principaux: Guo, Senli, Ray, Chad, Kirkpatrick, Andrea, Lad, Nimit, Akhremitchev, Boris B.
Format: Artigo
Langue:Inglês
Publié: The Biophysical Society 2008
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553120/
https://ncbi.nlm.nih.gov/pubmed/18621812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.133900
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