Enhancement of docetaxel-induced cytotoxicity and apoptosis by all-trans retinoic acid (ATRA) through downregulation of survivin (BIRC5), MCL-1 and LTbeta-R in hormone- and drug resistant prostate cancer cell line, DU-145

BACKGROUND: The management of hormone-refractory prostate cancer (HRPC) still remains as an important challenge of daily oncology practice. Docetaxel has proved to be a first line treatment choice. All-trans retinoic acid (ATRA) could potently inhibit the growth of prostate cancer cells in vitro and...

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Autores principales: Kucukzeybek, Yuksel, Gul, Mustafa K, Cengiz, Ercument, Erten, Cigdem, Karaca, Burcak, Gorumlu, Gurbuz, Atmaca, Harika, Uzunoglu, Selim, Karabulut, Bulent, Sanli, Ulus A, Uslu, Ruchan
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2008
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2553060/
https://ncbi.nlm.nih.gov/pubmed/18789152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-9966-27-37
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