Mutations in the major DNA-binding protein gene of herpes simplex virus type 1 result in increased levels of viral gene expression.

We have examined the effect of temperature-sensitive mutations in the herpes simplex virus 1 DNA-binding protein gene on viral gene expression. We have found that at the nonpermissive temperature, the synthesis of certain immediate early, early, and late viral polypeptides was greater in cells infec...

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Bibliographic Details
Main Authors: Godowski, P J, Knipe, D M
Format: Artigo
Language:Inglês
Published: 1983
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC255289/
https://ncbi.nlm.nih.gov/pubmed/6312079
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